muscle (1:5.1-1) unstable; urgency=medium

  * Next-generation MUSCLE *
  Muscle v5 is a major re-write of MUSCLE based on new algorithms.
  
  Users should be aware that command line arguments compared to version
  3.x of MUSCLE have changed!

  * Highest accuracy, scalable to thousands of sequences *
  Compared to previous versions, Muscle v5 is much more accurate, is often
  faster, and scales to much larger datasets. At the time of writing (late
  2021), Muscle v5 has the highest scores on multiple alignment benchmarks
  including Balibase, Bralibase, Prefab and Balifam. It can align tens of
  thousands of sequences with high accuracy on a low-cost commodity computer
  (say, an 8-core Intel CPU with 32 Gb RAM). On large datasets, Muscle v5
  is 20-30% more accurate than MAFFT and Clustal-Omega.

  * Alignment ensembles *
  Muscle v5 can generate ensembles of high-accuracy alternative alignments.
  All replicates have equal average accuracy on benchmark test, including
  the MSA made with default parameters. By comparing results of downstream
  analysis (trees, structure prediction...) on different replicates, you can
  assess the effects of alignment errors on your study. 

 -- Andreas Tille <tille@debian.org>  Mon, 17 Jan 2022 14:08:42 +0100
